DSC study on the effect of dimethysulfoxide (DMSO) and diethylsulfoxide (DESO) on phospholipid liposomes

In this paper, the DSC thermal behaviour of DMPC and DMPE liposomes in the presence of increasing amounts of both DMSO and DESO was investigated. In the presence of low amounts of both dialkylsulfoxides (DASO), the main effect was an increase in the transition temperatures, more enhanced in the presence of DMSO, together with an increase in the ΔH values, more enhanced in the presence of DESO. With a high sulfoxide content, a noticeable increase, with marked differences between the two compounds, was observed in all thermal parameters and the whole thermogram was strongly affected by memory effects.