Title of article
Antibacterial activities of manganese(II) ebselen–porphyrin conjugate and its free components on Staphylococcus aureus investigated by microcalorimetry
Author/Authors
Xiang-Jiao Xu، نويسنده , , Zhi Xue، نويسنده , , Zu-De Qi، نويسنده , , Xin Hou، نويسنده , , Chao-Hong Li، نويسنده , , Yi Liu، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2008
Pages
6
From page
33
To page
38
Abstract
The antibacterial effect of Mn(II), tetraphenyl porphyrin (TPP), ebselen–porphyrin conjugate 1 and its manganese(II) complex 2 towards Staphylococcus aureus growth was studied by stop-flow microcalorimetry. By analyzing the power–time curves, crucial parameters such as rate constant of bacterial growth (k), half inhibitory concentration (IC50), and generation time (tG) were determined. The sequence of the antibacterial activities of these compounds tested was 2 > 1 > Mn(II) > TPP, with an IC50 value of 100 μg/mL for complex 2. Manganese(II) ebselen–porphyrin conjugate 2 is proposed to benefit from synergetic effects of Mn(II) and 1.
Keywords
Ebselen–porphyrin conjugate , microcalorimetry , Thermokinetics , Antibacterial effects , Staphylococcus aureus
Journal title
Thermochimica Acta
Serial Year
2008
Journal title
Thermochimica Acta
Record number
1198297
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