In vitro release of incorporated model compounds in poly(sebacic anhydride-co-ethylene glycol)

Poly(sebacic anhydride-co-ethylene glycol) was synthesized by using sebacic anhydride prepolymer and poly(ethylene glycol) for encapsulation of p-nitroaniline and brilliant blue G as modeling drugs to investigate the behavior of hydrophobic and hydrophilic drug release, respectively. Since p-nitroaniline is likely located in the sebacic anhydride-rich phase and brilliant blue G in the PEG-rich phase, respectively, their incorporation would affect the phase behavior of the host polymer. Different pore structure of eroded polymer matrix and drug release behavior were identified for hydrophobic and hydrophilic compounds. With a certain amount of PEG in the copolymer matrix, low drug release rate was accomplished for hydrophobic drug incorporation.