Design of “smart” segmented polymers by incorporating random copolymers as building blocks

This article is dealing with the design of novel segmented polymers comprising homopolymer and random copolymer building blocks designated as block-random. This type of polymeric materials can be prepared through macromolecular engineering by using controlled polymerization methods. By replacing a homopolymer block with a random one, in block copolymer topologies, further tuning of the copolymer properties can be achieved. The present article highlights the recent developments on block-random segmented macromolecules, bearing building blocks of tunable properties (e.g. thermo-sensitivity (LCST), hydrophobicity) and exhibiting responsive behavior in aqueous environments. Furthermore, preliminary novel results regarding pH-sensitive segmented macromolecules of various topologies, bearing random polyampholyte blocks among others, are also demonstrated and discussed.