Title of article
Microscopic Enteritis; clinical features and correlations with symptoms
Author/Authors
Shahraki، Touran نويسنده Department of Pediatrics, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , , Rostami، Kamran نويسنده Department of Gastroenterology, Mid Staffordshire NHS Foundation Trust, Stafford , , Shahraki، Mansour نويسنده Department of Nutrition, and Research Center for Children and Adolescent Health, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan , , Bold، Justine نويسنده Institute of Health, Social Care and Psychology University of Worcester UK , , Danciu، Mihai نويسنده Department of Pathology, University of Medicine and Pharmacy Iasi, Romania , , Al Dulaimi، David نويسنده Department of Gastroenterology, Alexandra Hospital, Redditch , , Villanacci، Vincenzo نويسنده 2nd Department of Pathology, Spedali Civili University of Brescia Italy , , Bassotti، Gabrio نويسنده Gastroenterology and Hepatology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy ,
Issue Information
فصلنامه با شماره پیاپی سال 2012
Pages
9
From page
146
To page
154
Abstract
Aim: To assess the clinical characteristic of CD as well as correlation of symptoms and the degrees of intestinal mucosal lesions in Iranian children.
Background: Microscopic Enteritis (Marsh 0-II) is associated with malabsorption.
Patients and methods: From August 2005 to September 2009, 111 cases with malabsorption and classical gastrointestinal symptoms were evaluated.
Results: The mean (±SD) age of children with CD was 4.9±3.5 years (range, 6 month - 16 years) and the mean duration of symptoms was 8 ± 20.5 months. 50 cases (45%) were female and 61 cases (55%) were male. The most common clinical presentation was failure to thrive in 72%, chronic diarrhea in 65.8% and Iron deficiency anemia in 59.5%. Sensitivity of EMA was 100% in patients with Marsh IIIb and Marsh IIIc. EMA was also positive in 77% of cases with Marsh 0, 18% in Marsh I, 44% in Marsh II and 81.8% in patients with Marsh IIIa.
Conclusion: Histopathology did not reflect the severity of gluten sensitivity. This would suggest that the degree of intestinal mucosal damage might not be a reliable prognostic factor. Significant symptoms can be present with minor histological change on biopsy.
Journal title
Gastroenterology and Hepatology From Bed to Bench
Serial Year
2012
Journal title
Gastroenterology and Hepatology From Bed to Bench
Record number
1242497
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