Title of article
Apo and Inhibitor Complex Structures of BACE (β-secretase)
Author/Authors
Sahil Patel، نويسنده , , Laurent Vuillard، نويسنده , , Anne Cleasby، نويسنده , , Christopher W. Murray، نويسنده , , Jeff Yon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
10
From page
407
To page
416
Abstract
Human BACE, also known as β-secretase, shows promise as a potential therapeutic target for Alzheimerʹs disease. We determined the apo structure of BACE to 1.75 Å, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.
Keywords
Crystallography , BACE , Drug discovery , Alzheimerיs disease
Journal title
Journal of Molecular Biology
Serial Year
2004
Journal title
Journal of Molecular Biology
Record number
1244253
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