Title of article
Genomic and Proteomic Analysis of phiEco32, a Novel Escherichia coli Bacteriophage
Author/Authors
Dhruti Savalia، نويسنده , , Lars F. Westblade، نويسنده , , Manisha Goel، نويسنده , , Laurence Florens، نويسنده , , Priscilla Kemp، نويسنده , , Natalja Akulenko، نويسنده , , Olga Pavlova، نويسنده , , Julio C. Padovan، نويسنده , , Brian T. Chait and Michael P. Rout، نويسنده , , Michael P. Washburn، نويسنده , , Hans-W. Ackermann، نويسنده , , Arcady Mushegian، نويسنده , , Tarasii Gabisonia، نويسنده , , Ian Molineux، نويسنده , , Konstantin Seve، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
16
From page
774
To page
789
Abstract
A novel bacteriophage infecting Escherichia coli was isolated during a large-scale screen for bacteriophages that may be used for therapy of mastitis in cattle. The 77,554-bp genome of the bacteriophage, named phiEco32, was sequenced and annotated, and its virions were characterized by electron microscopy and proteomics. Two phiEco32-encoded proteins that interact with host RNA polymerase were identified. One of them is an ECF family σ factor that may be responsible for transcription of some viral genes. Another RNA polymerase-binding protein is a novel transcription inhibitor whose mechanism of action remains to be defined.
Keywords
Podoviridae , E. coli , MudPIT , GENOME , Bacteriophage
Journal title
Journal of Molecular Biology
Serial Year
2008
Journal title
Journal of Molecular Biology
Record number
1256426
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