Title of article
Synthesis and biology of 3′-N-acyl-N-debenzoylpaclitaxel analogues Original Research Article
Author/Authors
Eun Joo Roh، نويسنده , , Choong Eui Song، نويسنده , , Deukjoon Kim، نويسنده , , Hyun-Ock Pae، نويسنده , , Hun-Taeg Chung، نويسنده , , Kwan Sun Lee، نويسنده , , Ki-byung Chai، نويسنده , , Chong-Ock Lee، نويسنده , , Sang-Un Choi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
5
From page
2115
To page
2119
Abstract
The 3′-N-acyl-N-debenzoylpaclitaxel analogues were synthesized and evaluated on biological systems. Some of the analogues exhibited higher cytotoxicities (up to 20-fold) and stronger abilities to induce apoptosis than paclitaxel. In an in vivo experiment against ip implanted B16 melanoma, the most cytotoxic compound in vitro caused tumor growth inhibition more than paclitaxel.
Keywords
Cytotoxicity , apoptosis , Structure–activity relationship , 3?-N-Acyl-N-debenzoylpaclitaxel analogues
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300541
Link To Document