Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-ones (TIBO) analogues Original Research Article

4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk]benzodiazepin-2(1H)-ones (TIBO), , have been shown to significantly inhibit HIV-1 replication, as reported in detail in our prior publications. Since our earlier reports, we have modified the TIBO structures by removing the 5-membered ring of , generating 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-ones (TBO), , a bicyclic series of compounds. Although compounds possess modest activity when compared to TIBO analogues , they clearly demonstrated significant anti-HIV-1 activity.