Title of article
Towards the development of novel antibiotics: synthesis and evaluation of a mechanism-based inhibitor of Kdo8P synthase Original Research Article
Author/Authors
Shoucheng Du، نويسنده , , Hana Faiger، نويسنده , , Valery Belakhov، نويسنده , , Timor Baasov، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
12
From page
2671
To page
2682
Abstract
The design and two synthetic pathways to aminophosphonate which mimics the ionic and steric properties of putative oxocarbenium intermediate in the Kdo8P synthase-catalyzed reaction are reported. It was found that is a slow-binding, most potent inhibitor of the enzyme yet tested, with a Ki value of 0.4 μM.
Keywords
KDO8P synthase , Lipopolysaccharide , Mechanism-based inhibitors
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300677
Link To Document