Title of article
Synthesis and evaluation as glycosidase inhibitors of 2,5-imino-d-glucitol and 1,5-imino-d-mannitol related derivatives Original Research Article
Author/Authors
Isabelle McCort، نويسنده , , Sébastien Fort، نويسنده , , Annie Duréault، نويسنده , , Jean-Claude Depezay، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
9
From page
135
To page
143
Abstract
Selectively functionalized 2,5-imino-d-glucitol and 1,5-imino-d-mannitol derivatives were synthesized and tested as precursors of hydrolytically resistant pseudo-disaccharides. Among them N-acetyl-6-amino-6-deoxy-2,5-imino-d-glucitol () and N-acetyl-6-amino-6-deoxy-1,5-imino-d-mannitol () were found potent and specific inhibitors against β-d-glucosidase and α-l-fucosidase, respectively.
Keywords
C2 symmetric bis-aziridine , Azasugars , ?-d-glucosidase inhibitor , ?-l-fucosidase inhibitor
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2000
Journal title
Bioorganic and Medicinal Chemistry
Record number
1300796
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