Title of article
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity Original Research Article
Author/Authors
Fabrizio Micheli، نويسنده , , Alfredo Cugola، نويسنده , , Daniele Donati، نويسنده , , Andrea Missio، نويسنده , , Angelo Pecunioso، نويسنده , , Angelo Reggiani، نويسنده , , Giorgio Tarzia، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
4
From page
2129
To page
2132
Abstract
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo.
Keywords
Glycine , NMDA , 3-b]pyrazine , Stroke , MCAO
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301405
Link To Document