Title of article
Nitroarylhydroxymethylphosphonic acids as inhibitors of CD45 Original Research Article
Author/Authors
Scott A. Beers، نويسنده , , Elizabeth A. Malloy، نويسنده , , Wei Wu، نويسنده , , Michael P. Wachter، نويسنده , , Uma Gunnia، نويسنده , , Druie Cavender، نويسنده , , Crafford Harris، نويسنده , , Janet Davis، نويسنده , , Ruth Brosius، نويسنده , , J. Lee Pellegrino-Gensey، نويسنده , , John Siekierka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
9
From page
2203
To page
2211
Abstract
A series of nitroarylhydroxymethylphosphonic acids was synthesized and evaluated as inhibitors of CD45. It was discovered that both the alpha hydroxy and nitro groups are essential for activity. Potency is enhanced by the addition of a large lipophilic group on the aryl ring adjacent to the phosphonic acid moiety. Kinetics studies have shown that these compounds are competitive inhibitors and thus bind at the active site of this enzyme
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1997
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301416
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