Title of article
Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2 Original Research Article
Author/Authors
Frédérique Tellier، نويسنده , , Francine Acher، نويسنده , , Isabelle Brabet، نويسنده , , Jean-Philippe Pin، نويسنده , , Robert Azerad، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
14
From page
195
To page
208
Abstract
Isomeric norbornane-derived rigid analogs mimicking different potential conformations of ACPD (1-aminocyclopentane-1,3-dicarboxylic acid) and glutamic acid have been synthesized, via the hydantoin route, to be used as conformational probes for bioactive conformations at the glutamatergic receptors of the central nervous system. Activities on metabotropic receptors mGluR1 and mGluR2 are reported and discussed.
Keywords
metabotropic receptors , aminocyclopentane-1 , 3-dicarboxylic acid (ACPD) , Norbornane analog , Glutamic acid , conformation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301463
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