Title of article
Synthesis and Inhibitory Activity of Novel Tri- and Tetracyclic Quinolines against Topoisomerases Original Research Article
Author/Authors
Zhihua Sui، نويسنده , , Jason Altom، نويسنده , , Van N. Nguyen، نويسنده , , Jeff Fernandez، نويسنده , , Jeff I. Bernstein، نويسنده , , Jamese J. Hiliard، نويسنده , , John F. Barrett، نويسنده , , Brent L. Podlogar، نويسنده , , Kwasi A. Ohemeng، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
8
From page
735
To page
742
Abstract
A series of isoindolo[2,1-a]- and pyrrolo[1,2-a]quinolines were designed and synthesized for DNA-gyrase and topoisomerase-II inhibition studies. Some of the compounds showed significant activity against the enzymes.
Keywords
2-a]quinolines , DNA-gyrase , topoisomerase II , 1-a]quinolines
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301556
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