Title of article
Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor Original Research Article
Author/Authors
Sylvie Bourrain، نويسنده , , Ian Collins، نويسنده , , Joseph G. Neduvelil، نويسنده , , Michael Rowley، نويسنده , , Paul D. Leeson، نويسنده , , Smita Patel، نويسنده , , Shil Patel، نويسنده , , Frances Emms، نويسنده , , Rosemarie Marwood، نويسنده , , Kerry L. Chapman، نويسنده , , Alan E. Fletcher، نويسنده , , Graham A. Showell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
13
From page
1731
To page
1743
Abstract
Two novel series of 3-(heterocyclylmethyl)pyrazoles have been synthesised and evaluated as ligands for the human dopamine D4 receptor. Compounds in series I (exemplified by 8k) have a phenyl ring joined to the 4-position of the pyrazole while those in series II (exemplified by 15j) have a 5-phenyl ring linked by a saturated chain to the 4-position of the pyrazole. Both series supplied compounds with excellent affinity for the human D4 and good selectivity over other dopamine receptors. Excellent selectivity over calcium, sodium, and potassium ion channels was also achieved.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301715
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