Title of article
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1–DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin Original Research Article
Author/Authors
Hanumantharao G. Raj، نويسنده , , Virinder S. Parmar، نويسنده , , Subhash C. Jain، نويسنده , , Sanjay Goel، نويسنده , , Amarjit Singh، نويسنده , , Kshitij Gupta، نويسنده , , Vishwajeet Rohil، نويسنده , , Yogesh K Tyagi، نويسنده , , Hirday N. Jha، نويسنده , , Carl E Olsen، نويسنده , , Jesper Wengel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
10
From page
1895
To page
1904
Abstract
7,8-Diacetoxy-4-methylcoumarin (DAMC), with no prerequisite for oxidative biotransformation has been reported to produce suicide inactivation of microsomal cytochrome P-450-catalysed formation of aflatoxin B1-8,9-oxide that binds to DNA. Parenteral administration of DAMC to rats caused significant inhibition of AFB1 binding to hepatic DNA in vivo as well as AFB1-induced micronuclei formation in bone marrow cells. These results highlight the antimutagenic potential of DAMC.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1998
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301782
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