Title of article
5-Demethylovalicin, as a Methionine Aminopeptidase-2 Inhibitor Produced by Chrysosporium Original Research Article
Author/Authors
Kwang-Hee Son، نويسنده , , Ju-Young Kwon، نويسنده , , Ha-Won Jeong، نويسنده , , Hyae-Kyeong Kim، نويسنده , , Chang-Jin Kim، نويسنده , , Yie-Hwa Chang، نويسنده , , Jung-Do Choi، نويسنده , , Byoung-Mog Kwon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
185
To page
188
Abstract
5-Demethylovalicin was isolated from the fermentation broth Chrysosporium lucknowense and the structure was identified by spectroscopic methods. 5-Demethylovalicin inhibited the recombinant human MetAP-2 (IC50=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC50=100 nM) in cell proliferation assay without cytotoxicity on the transformed and cancer cell lines.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1301954
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