• Title of article

    Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: synthesis and biological activities of triazine derivatives Original Research Article

  • Author/Authors

    F Leroux، نويسنده , , B.J van Keulen، نويسنده , , J Daliers، نويسنده , , N Pommery، نويسنده , , J.P Hénichart، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1999
  • Pages
    8
  • From page
    509
  • To page
    516
  • Abstract
    A series of triazine derivatives was synthesized. The compounds were evaluated for tracheal smooth muscle relaxant and type 4 phosphodiesterase inhibitory activities. A highly significant correlation was observed between the two effects. Two compounds exhibited potent relaxant activity (EC50: 17 and 24 nM) and might be useful for the treatment of asthma.
  • Keywords
    bronchodilators , Enzyme inhibitors , antiinflammatories , Substituent effects
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Serial Year
    1999
  • Journal title
    Bioorganic and Medicinal Chemistry
  • Record number

    1302003

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1302003