Title of article
Dihydroxybergamottin Caproate as a Potent and Stable CYP3A4 Inhibitor Original Research Article
Author/Authors
Tomihisa Ohta، نويسنده , , Minoru Nagahashi، نويسنده , , Shinzo Hosoi، نويسنده , , Sachiko Tsukamoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
969
To page
973
Abstract
We investigated the inhibitory activity of the furanocoumarin derivatives from grapefruit juice to the drug metabolizing enzyme, cytochrome P450 (CYP) 3A4. Although two known furanocoumarin dimers GF-I-1 (1) and GF-I-4 (2) showed potent CYP3A4 inhibition with IC50 value of 0.07 μM, a semi-synthetic dihydroxybergamottin caproate (11), which was more stable and more simple than the dimers, exhibited comparable activity against CYP3A4.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302038
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