Title of article
RAR–RXR Selectivity and Biological Activity of New Retinoic Acid Analogues with Heterocyclic or Polycyclic Aromatic Systems Original Research Article
Author/Authors
D. Ivanova، نويسنده , , C. Gaudon، نويسنده , , A. Rossin، نويسنده , , W. Bourguet، نويسنده , , H. Gronemeyer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2099
To page
2102
Abstract
The cell biological activity of novel retinoids and rexinoids is described. The stereochemistry of the new compounds was analyzed and ligand docking experiments revealed the structural basis of their RAR binding characteristics. The new ligands activate nuclear retinoic acid receptors (RAR, RXR) with distinct selectivity patterns, as determined in genetically engineered ‘reporter’ cells. The biological activity of the novel retinoids was assessed by differentiation of NB4 acute promyelocytic leukemia cells. © 2002 Elsevier Science Ltd. All rights reserved.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2002
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302140
Link To Document