Title of article
Synthesis and structure–affinity relationships at the central benzodiazepine receptor of pyridazino[4,3-b]indoles and Indeno[1,2-c]pyridazines Original Research Article
Author/Authors
F Campagna، نويسنده , , F. Palluotto، نويسنده , , A Carotti، نويسنده , , G Casini، نويسنده , , G Genchi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1533
To page
1538
Abstract
A series of 2-aryl-3-chloro-2H-pyridazino[4,3-b]indoles, 2-aryl-3-methoxy-2H-pyridazino[4,3-b]indoles, and 2-aryl-2,5-dihydroindeno[1,2-c]pyridazino-3(3H)-ones has been prepared and tested for their ability to inhibit the [3H]flunitrazepam binding to the central benzodiazepine receptor. SAR are presented and discussed in comparison with existing pharmacophore models.
Keywords
benzodiazepine receptor , Structure–activity relationships , Binding assay , 3-b]indoles , 2-c]pyridazines
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
1999
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302360
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