Title of article
Anti-MRSA cephems. Part 2: C-7 cinnamic acid derivatives Original Research Article
Author/Authors
Dane M. Springer، نويسنده , , Bing-Yu Luh، نويسنده , , Jason Goodrich، نويسنده , , Joanne J. Bronson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
15
From page
265
To page
279
Abstract
Forty-five novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel cinnamic acid moieties at C-7 that were synthesized using a key Heck reaction followed by nucleophilic aromatic substitution reactions. The most active compound (41) displayed an MIC90 against MRSA of 1.0 μg/mL, and a PD50 of 0.8 mg/kg. Compound 14 was found to be very safe in a mouse model of acute toxicity.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302520
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