Title of article
Effect of Aryl Ring Fluorination on the Antibacterial Properties of C4 Aryl-Substituted N-Methylthio β-Lactams Original Research Article
Author/Authors
Timothy E. Long، نويسنده , , Edward Turos، نويسنده , , Monika I. Konaklieva، نويسنده , , Allison L Blum، نويسنده , , Amal Amry، نويسنده , , Ejae A Baker، نويسنده , , Lita S Suwandi، نويسنده , , Melodie D McCain، نويسنده , , Miti F Rahman، نويسنده , , Sonja Dickey، نويسنده , , Daniel V Lim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
1859
To page
1863
Abstract
4-Aryl-substituted N-thiolated β-lactams are a new family of antibacterial agents possessing unique structure–activity profiles and a mode of action. Unlike traditional β-lactam antibiotics, which require highly polar enzyme-binding groups, these lactams bear hydrophobic groups on their side chains. In this study, we examine the effect that increasing hydrophobicity, through fluorine substitution in the C4 aryl ring, has on the antibacterial properties.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302673
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