Title of article
Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives Original Research Article
Author/Authors
Mauricio A. Cuellar، نويسنده , , Cristian Salas، نويسنده , , Manuel J. Cortés، نويسنده , , Antonio Morello، نويسنده , , Juan Diego Maya، نويسنده , , Marcelo D. Preite، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
9
From page
2489
To page
2497
Abstract
The Diels–Alder reaction between two polygodial-derived dienes and simple quinones to yield substituted naphtho- and anthraquinones, is described. The in vitro trypanocide activity for the series was determined. Two of the new compounds showed an activity ten and two times higher, respectively, than nifurtimox and benznidazole, the medicines of choice for the treatment of the acute Chagasʹ disease.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302737
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