Title of article
Antisense phosphorothioate oligodeoxyribonucleotide targeted against ICAM-1: synthetic and biological characterization of a process-related impurity formed during oligonucleotide synthesis Original Research Article
Author/Authors
Vasulinga T. Ravikumar، نويسنده , , Daniel C. Capaldi، نويسنده , , Walt F. Lima، نويسنده , , Elena Lesnik، نويسنده , , Brett Turney، نويسنده , , Douglas L. Cole، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
7
From page
4673
To page
4679
Abstract
A phosphorothioate-linked oligonucleotide bearing a 3′-terminal phosphorothioate monoester has been synthesized and characterized. This oligonucleotide has been identified as a process-related impurity formed during synthesis of ISIS 2302. Biological properties of the compound have been determined. Based on these data, it can be concluded that this species (3′-TPT) has biological properties similar to parent drug.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302787
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