Title of article
Synthesis and in vitro evaluation of potential antichagasic hydroxymethylnitrofurazone (NFOH-121): a new nitrofurazone prodrug Original Research Article
Author/Authors
Man-Chin Chung، نويسنده , , Rafael Vict?rio Carvalho Güido، نويسنده , , Tatiane Favarato Martinelli، نويسنده , , Marinei Ferreira Gonçalves، نويسنده , , Michelle Carneiro Polli، نويسنده , , Katia Cirlene Alves Botelho، نويسنده , , Eliana Aparecida Varanda، نويسنده , , Walter Colli، نويسنده , , M. Terêsa M. Miranda، نويسنده , , Elizabeth Igne Ferreira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
4779
To page
4783
Abstract
The synthesis of mutual prodrugs of nitrofurazone with primaquine, using specific and nonspecific spacer groups, has been previously attempted seeking selective antichagasic agents. The intermediate reaction product, hydroxymethylnitrofurazone (NFOH-121), was isolated and tested in LLC-MK2 culture cells infected with trypomastigotes forms of Trypanosoma cruzi showing higher trypanocidal activity than nitrofurazone and benznidazol in all stages. The mutagenicity tests showed that the prodrug was less toxic than the parent drug. Degradation assays were carried out in pH 1.2 and 7.4.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2003
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302797
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