Title of article
Saturation-transfer difference NMR studies for the epitope mapping of a carbohydrate-mimetic peptide recognized by an anti-carbohydrate antibody Original Research Article
Author/Authors
Margaret A. Johnson، نويسنده , , B. Mario Pinto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
295
To page
300
Abstract
Saturation-transfer difference NMR spectroscopy (STD-NMR) experiments have been performed to analyze the topography or epitope of the octapeptide MDWNMHAA recognized by the anti-carbohydrate antibody SYA/J6 in solution; the antibody is directed against the Shigella flexneri Y O-antigen polysaccharide. The results permit a valuable comparison of solution versus crystal-structure data, and provide insight for the design of the next-generation binding ligands.
Keywords
saturation-transfer difference NMR , peptide epitope mapping , molecular recognition in solution vs. solid state , peptide-carbohydrate mimicry
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1302864
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