Title of article
Synthesis and immunomodulatory properties of selected oxazolone derivatives Original Research Article
Author/Authors
Muhammad A Mesaik، نويسنده , , Shagufta Rahat، نويسنده , , Khalid M Khan، نويسنده , , Zia-Ullah، نويسنده , , Muhammad Iqbal Choudhary، نويسنده , , Shahnaz Murad، نويسنده , , Zakiah Ismail، نويسنده , , Atta-ur-Rahman، نويسنده , , Aqeel Ahmad، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
9
From page
2049
To page
2057
Abstract
Eleven oxazolone derivatives were synthesized and characterized by 1H NMR, EI, IR and UV spectroscopic and CHN analysis. Three compounds, 4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one (11), 4-[(E)-(4-methoxyphenyl)methylidene]-2-methyl-1,3-oxazol-5-one (12) and 4-[(E)-(4-nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) were screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. 4-[(E)-(4-Nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) was found to be the most potent immunomodulator in the series.
Keywords
Oxazolone , T-Cell proliferation , Immunomodulation , chemotaxis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303019
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