Title of article
Versatile approach for the synthesis of novel seven-membered iminocyclitols via ring-closing metathesis dihydroxylation reaction Original Research Article
Author/Authors
Chang-Ching Lin، نويسنده , , Yi-shin Pan، نويسنده , , Laxmikant N Patkar، نويسنده , , Hsiu-Mei Lin، نويسنده , , Der-Lii M. Tzou، نويسنده , , Thangaiah Subramanian، نويسنده , , Chun-Cheng Lin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
9
From page
3259
To page
3267
Abstract
Seven-membered iminocyclitols with diverse diastereomers were prepared starting with d- and l-serines and employing ring-closing olefin metathesis and dihydroxylation reaction sequence. The iminocyclitols were assayed for glycosidase inhibition and compound 20 was found to be a competitive inhibitor for β-glucosidase with Ki 26.3 μM.
Keywords
Iminocyclitols , Glycosidase inhibitor , Dihydroxylation , Ring-closing metathesis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303129
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