Title of article
Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides Original Research Article
Author/Authors
Andreas Mitsch، نويسنده , , Pia Wi?ner، نويسنده , , Katrin Silber، نويسنده , , Peter Haebel، نويسنده , , Isabel Sattler، نويسنده , , Gerhard Klebe، نويسنده , , Martin Schlitzer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
16
From page
4585
To page
4600
Abstract
We have designed arylfurylacryl-substituted benzophenones as non-thiol farnesyltransferase inhibitors utilizing a novel aryl binding site of farnesyltransferase. These compounds display activity in the low nanomolar range.
Keywords
Structure–activity relationships , Non-thiol farnesyltransferase inhibitors
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2004
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303229
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