Title of article
Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists Original Research Article
Author/Authors
William F. Kiesman، نويسنده , , Jin Zhao، نويسنده , , Patrick R. Conlon، نويسنده , , Russell C. Petter، نويسنده , , Xiaowei Jin، نويسنده , , Glenn Smits، نويسنده , , Frank Lutterodt، نويسنده , , Gail W. Sullivan، نويسنده , , Joel Linden، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
3654
To page
3661
Abstract
During the search for second-generation adenosine A1 receptor antagonist alternatives to the clinical candidate 8-(3-oxa-tricyclo[3.2.1.02,4]oct-6-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione (BG9719), we developed a series of novel xanthines substituted with norbornyl-lactones that possessed high binding affinities for adenosine A1 receptors and in vivo activity.
Keywords
MRSA , SAR , Antibiotics , N-Thiolated ?-lactams
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303450
Link To Document