Title of article
Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity Original Research Article
Author/Authors
Maria H. Paluchowska، نويسنده , , Ryszard Bugno، نويسنده , , Andrzej J. Bojarski، نويسنده , , Sijka Charakchieva-Minol، نويسنده , , Beata Duszynska، نويسنده , , Ewa Tatarczy?ska، نويسنده , , Aleksandra K?odzi?ska، نويسنده , , Katarzyna Stachowicz، نويسنده , , Ewa Chojnacka-W?jcik، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
1195
To page
1200
Abstract
Novel, flexible arylpiperazine gepirone analogs (1a–3a) with a mixed 5-HT1A/5-HT2A receptor profile, low D2 receptor affinity, and agonistic (2a) or partial agonistic (1a, 3a) activity toward 5-HT1A receptor sites were synthesized. Their conformationally restricted counterparts (1b–3b) were selective 5-HT1A ligands (over 5-HT2A and D2 receptors), which turned out to be agonists (2b, 3b), or partial agonist (1b) of 5-HT1A receptors.
Keywords
5-HT1A/5-HT2A Receptor ligands , 5-HT1A Receptor agonists and partial agonists , Flexible and conformationally defined gepirone analogs , Selective 5-HT1A receptor ligands
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303624
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