Title of article
Syntheses of quinolone hydrochloride enantiomers from synthons (R)- and (S)-2-methylpiperazine Original Research Article
Author/Authors
Bo Liu، نويسنده , , Chunhao Yang، نويسنده , , Guangyu Xu، نويسنده , , Yong-Hong Zhu، نويسنده , , Jing-Rong Cui، نويسنده , , Xihan Wu، نويسنده , , Yuyuan Xie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
2451
To page
2458
Abstract
A series of R and S enantiomers of 7-(3-methylpiperazin-1-yl) quinolone derivatives were synthesized from (R)- and (S)-tert-butyl 2-methylpiperazine-1-carboxylate and tested for their antibacterial activities on 14 kinds of bacteria. Although no distinct difference in in vitro antibacterial activities was observed, 2–64-fold difference between R and S enantiomers was observed in approximately 52% of cases.
Keywords
Methylpiperazine , Antibacterial activity , Synthon , Quinolone
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303768
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