Title of article
Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion Original Research Article
Author/Authors
Andreas Marc Palmer، نويسنده , , Burkhard Grobbel، نويسنده , , Christof Brehm، نويسنده , , Peter Jan Zimmermann، نويسنده , , Wilm Buhr، نويسنده , , Martin Philipp Feth، نويسنده , , Hans Christof Holst، نويسنده , , Wolfgang-Alexander Simon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
14
From page
7647
To page
7660
Abstract
A series of novel tetrahydroimidazo[2,1-a]isoquinolines was prepared based on a hetero Diels–Alder reaction between an enamine and 1,2,4-triazine as key step. A structure–activity relationship was established focussing on the influence of the substitution pattern in position 3 and 6 of the heterocycle on antisecretory activity, lipophilicity, and pKa value. Potent inhibitors of the gastric acid pump were identified.
Keywords
hetero Diels–Alder reaction , 1-a]isoquinolines , Antisecretory activity , Gastric acid pump , H+/K+-ATPase
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303850
Link To Document