Title of article
Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives Original Research Article
Author/Authors
Aline F. Taveira، نويسنده , , Mireille Le Hyaric، نويسنده , , Elaine F.C. Reis، نويسنده , , Débora P. Ara?jo، نويسنده , , Ana Paula Ferreira، نويسنده , , Maria Aparecida de Souza، نويسنده , , L?via L. Alves، نويسنده , , Maria C.S. Lourenço، نويسنده , , Felipe Rodrigues C. Vicente، نويسنده , , Mauro V. de Almeida، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
7789
To page
7794
Abstract
A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5 μg/mL. The presence of the carbohydrate slightly affected the antibacterial activity.
Keywords
N-Alkylation , Mycobacterium tuberculosis , amino alcohol , d-Galactose
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303864
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