Title of article
Synthesis and pharmacological activity of aminoindanone dimers and related compounds Original Research Article
Author/Authors
H. Sheridan، نويسنده , , S. Butterly، نويسنده , , J.J. Walsh، نويسنده , , C. Cogan، نويسنده , , M. Jordan، نويسنده , , O. Nolan، نويسنده , , N. Frankish، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
248
To page
254
Abstract
A series of N-substituted 3-aminoindanones were synthesised and evaluated for smooth muscle relaxant activity and mediator release inhibition effects. A low level of smooth muscle relaxant activity has been identified in all derivatives. Data have revealed that the significant mediator release inhibition effects observed are related to the nature of the amine substituents. A structure activity relationship is proposed.
Keywords
antiproliferative activity , Molecular-simplification strategy , Naphthylnitrobutadienes , Mechanism of action
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303897
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