Title of article
Synthesis, cytotoxic evaluation, and DNA binding of novel thiazolo[5,4-b]quinoline derivatives Original Research Article
Author/Authors
Marco A. Loza-Mej?a، نويسنده , , Karina Maldonado-Hern?ndez، نويسنده , , Fernando Rodr?guez-Hern?ndez، نويسنده , , Rogelio Rodr?guez-Sotres، نويسنده , , Ignacio Gonz?lez-S?nchez، نويسنده , , Angelina Quintero، نويسنده , , José D. Solano، نويسنده , , Alfonso Lira-Rocha، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
1142
To page
1149
Abstract
A series of novel alkylamino and 9-anilinothiazolo[5,4-b]quinolines were synthesized as potential antitumoral agents. The in vitro cytotoxicity of these compounds was evaluated on several cell lines. The inclusion of electron-withdrawn/acceptor hydrogen-bond groups at position 3′ of the anilino ring and the presence of an alkylamino chain on the tricyclic framework (regardless of its position) seem to be structural features relevant to cytotoxic activity.
Keywords
4-b]quinoline derivatives , Cytotoxic activity , Structure–activity relationship , DNA binding , Antitumoral
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1303980
Link To Document