Title of article
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-l-homocysteine hydrolase Original Research Article
Author/Authors
Takayuki Ando، نويسنده , , Masafumi Iwata، نويسنده , , Fazila Zulfiqar، نويسنده , , Tatsuya Miyamoto، نويسنده , , Masayuki Nakanishi، نويسنده , , Yukio Kitade، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
3809
To page
3815
Abstract
2-Modified aristeromycin derivatives and their related analogs were synthesized to investigate their inhibitory activity against human and Plasmodium falciparum S-adenosyl-l-homocysteine hydrolase (PfSAHH). 2-Fluoroaristeromycin showed a strong inhibitory activity against PfSAHH selectively and complete resistance to adenosine deaminase.
Keywords
S-Adenosyl-l-homocysteine hydrolase , Enzyme inhibitor , 2-Fluoroaristeromycin , Carbocyclic nucleoside
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304212
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