Title of article
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold Original Research Article
Author/Authors
GuoGang Tu، نويسنده , , Shaohua Li، نويسنده , , Huiming Huang، نويسنده , , Gang Li، نويسنده , , Fang Xiong، نويسنده , , Xi Mai، نويسنده , , and Huawei Zhu، نويسنده , , BinHai Kuang، نويسنده , , Wen Fang Xu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
6663
To page
6668
Abstract
The aminopeptidase N (APN/CD13), overexpressed in tumor cells, plays a critical role in angiogenesis. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent inhibitory activities toward APN with IC50 values in the micromol rang.
Keywords
Enzyme inhibitors , Aminopeptidase N , peptidomimetics
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304470
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