Title of article
Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones Original Research Article
Author/Authors
Oya Bozda?-Dündar، نويسنده , , Eugen J. Verspohl، نويسنده , , Net Da?-Evcimen، نويسنده , , Rebecca M. Kaup، نويسنده , , Katrin Bauer، نويسنده , , Mutlu Sar?kaya، نويسنده , , Begüm Evranos، نويسنده , , Rahmiye Ertan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
6747
To page
6751
Abstract
A new series of flavonyl-2,4-thiazolidinediones (Va–c, VIa–c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6 mmol/l glucose. Compounds VIa–c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%).
Keywords
Insulinotropic activity , Aldose reductase inhibition , Antidiabetic agents , Synthesis , Flavone , 2 , Flavonyl-2 , 4-Thiazolidinediones , 4-Thiazolidinediones
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304481
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