Title of article
Search for α-glucosidase inhibitors: New N-substituted valienamine and conduramine F-1 derivatives Original Research Article
Author/Authors
Robert ?ysek، نويسنده , , Catherine Schütz، نويسنده , , Sylvain Favre، نويسنده , , Anthony C. O’Sullivan، نويسنده , , Christian Pillonel، نويسنده , , Thomas Krülle، نويسنده , , Pierre M.J. Jung، نويسنده , , Imma Clotet-Codina، نويسنده , , José A. Esté، نويسنده , , Jean-Claude Hausmann and Pierre Vogel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
28
From page
6255
To page
6282
Abstract
A solid-phase synthesis of new N-substituted valienamines has been developed and new synthesis of (±)-conduramine F-1, (−)-conduramine F-1, and (+)-ent-conduramine F-1 is presented, together with the preparation of N-benzylated conduramines F-1. N-Benzylation of both valienamine and (+)-ent-conduramine F-1 improves their inhibitory activity toward α-glucosidases significantly. The additional hydroxymethyl group makes valienamine derivatives more active than their (+)-ent-conduramine F-1 analogues.
Keywords
‘Naked sugars’ , Imines , Cytotoxicity , Conduramine F-1 (aminoconduritol) , Solid-phase synthesis , ?-Glucosidase inhibitors
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305077
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