Title of article
A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors Original Research Article
Author/Authors
Lucie Vandromme، نويسنده , , Michel Legraverend، نويسنده , , Sergio Kreimerman، نويسنده , , Olivier Lozach، نويسنده , , Laurent Meijer، نويسنده , , David S. Grierson and Robert W. Carpick، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
12
From page
130
To page
141
Abstract
Two new series of 2-amido- and 2-aminocarbonylpurines have been synthesized using a Pd catalyst cross-coupling reaction either with amides or amines in the presence of CO. Moderate in vitro inhibitory activity against CDK1 and CDK5 was observed with IC50 of 0.9 μM for the most active compound (18c).
Keywords
Amidation , Carbonylative amination , CDK inhibitors , Amidopurine , Purine
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305259
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