Title of article
Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke Original Research Article
Author/Authors
Harunobu Mukaiyama، نويسنده , , Toshihiro Nishimura، نويسنده , , Satoko Kobayashi، نويسنده , , Tomonaga Ozawa، نويسنده , , Noboru Kamada، نويسنده , , Yoshimitsu Komatsu، نويسنده , , Shinji Kikuchi، نويسنده , , Hideki Oonota، نويسنده , , Hiroshi Kusama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
18
From page
868
To page
885
Abstract
We synthesized and evaluated a series of C-5 substituted imidazo[1,5-a]pyrazine derivatives to identify potent c-Src inhibitors as potential therapeutic agents for acute ischemic stroke. Among these compounds, compound 14c·HCl demonstrated remarkable central nervous system (CNS) penetration and significant neuroprotective efficacy in vivo in rat models.
Keywords
CH–? interaction , c-Src , Brain ischemia , 5-a]pyrazine , Central nervous system (CNS) penetration
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305330
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