A simple, yet highly accurate, QSAR model captures the complement inhibitory activity of compstatin Original Research Article

Compstatin is a 13-residue cyclic peptide inhibitor of complement activation that was originally identified through phage-mediated presentation of a peptide library to C3b. Recent efforts to improve its activity have led to a rich dataset of complement analogs, with the most active analog being ∼260 times more active than the parent compstatin. In the presen