Title of article
Benzoic acid and pyridine derivatives as inhibitors of Trypanosoma cruzi trans-sialidase Original Research Article
Author/Authors
Jo?o Neres، نويسنده , , Pascal Bonnet، نويسنده , , Philip N. Edwards، نويسنده , , Pravin L. Kotian، نويسنده , , Alejandro Buschiazzo، نويسنده , , Pedro M. Alzari، نويسنده , , Richard A. Bryce، نويسنده , , Kenneth T. Douglas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
14
From page
2106
To page
2119
Abstract
Benzoic acid and pyridine derivatives inhibit recombinant trans-sialidase from Trypanosoma cruzi with I50 values between 0.4 and 1 mM. The best compounds, 4-acetylamino-3-hydroxymethylbenzoic acid and 5-acetylamino-6-aminopyridine-2-carboxylic acid, provide new leads to inhibitors not containing the synthetically complex sialic acid structure. The weak inhibition by such compounds contrasts with their much stronger inhibition of neuraminidase from Influenza virus.
Keywords
Inhibitors , Neuraminidase , Trans-sialidase , Chagas disease
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305417
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