Title of article
Clubbed thiazoles by MAOS: A novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer’s disease Original Research Article
Author/Authors
Mahendra Ramesh Shiradkar، نويسنده , , Kalyan Chakravarthy Akula، نويسنده , , Varaprasad Dasari، نويسنده , , Vijayakumar Baru، نويسنده , , Bhoomeshwar Chiningiri، نويسنده , , Santosh Gandhi، نويسنده , , Ranjit Kaur، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
10
From page
2601
To page
2610
Abstract
A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer’s disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer’s disease.
Keywords
Thiazole , Triazole , Alzheimer’s disease , CDK5/p25
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305452
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