Title of article
Absolute stereochemistry and antitumor activity of iejimalides Original Research Article
Author/Authors
Kohei Nozawa، نويسنده , , Masashi Tsuda، نويسنده , , Haruaki Ishiyama، نويسنده , , Takuma Sasaki، نويسنده , , Takashi Tsuruo، نويسنده , , Jun’ichi Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
1063
To page
1067
Abstract
The absolute configurations at five chiral centers, except for C-32(S) reported previously, in iejimalides A, C, and D, potent cytotoxic 24-membered macrolides isolated from a tunicate Eudistoma cf. rigida, were assigned as 4R, 9S, 17S, 22S, and 23S on the basis of detailed analysis of NMR data and chemical means. Furthermore, the structures proposed for iejimalides A, C, and D were revised to their 13Z-isomers. Iejimalides A–D (1–4) exhibited antitumor activity in vivo.
Keywords
macrolide , Absolute configuration , Tunicate
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305486
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