Title of article
Effect of polycyclic cage amines on the transmembrane potential of neuronal cells Original Research Article
Author/Authors
Erika Grobler، نويسنده , , Anne Grobler، نويسنده , , Cornelis J. Van der Schyf، نويسنده , , Sarel F. Malan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
1176
To page
1181
Abstract
A series of pentacycloundecylamine derivatives were synthesized and their influence on the transmembrane potential of human SH-SY5Y neuroblastoma cells was evaluated using laser scanning confocal microscopy in combination with the potentiometric dye tetramethylrhodamine methyl ester. Results indicate that these derivatives influence the profile of KCl-induced membrane depolarization and cause an overall reduction in cell membrane depolarization.
Keywords
SH-SY5Y cells , Laser scanning confocal microscopy , Pentacycloundecylamines , Transmembrane potential
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305498
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