Title of article
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position Original Research Article
Author/Authors
Ken-ichi Yoshida، نويسنده , , Kiyoshi Nakayama، نويسنده , , Noriko Kuru، نويسنده , , Shozo Kobayashi، نويسنده , , Masami Ohtsuka، نويسنده , , Makoto Takemura، نويسنده , , Kazuki Hoshino، نويسنده , , Hiroko Kanda، نويسنده , , Jason Z. Zhang، نويسنده , , Ving J. Lee، نويسنده , , William J. Watkins، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
12
From page
1993
To page
2004
Abstract
A series of 4-oxo-4H-pyrido[1,2-a]pyrimidine derivatives, derivatized at the 2-position with carbon-linked substituents, were synthesized and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin (LVFX) and the anti-pseudomonas β-lactam aztreonam (AZT) in Pseudomonas aeruginosa. Palladium-catalyzed cross-coupling methods were applied for the incorporation of aliphatic and aromatic substituents.
Keywords
Pseudomonas aeruginosa , Drug resistance , Efflux pump inhibitor , MexAB-OprM efflux pump
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305579
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